To resolve Office 2021 issues, begin by ensuring your software is up to date with the latest updates and patches. If you encounter problems with applications like Word, Excel, or PowerPoint, try restarting your computer, as this can often resolve minor glitches. Additionally, check for conflicting add-ins or extensions and disable them if necessary. If Office 2021 still doesn’t function properly, consider repairing the installation through the Control Panel (Windows) or Applications (Mac). In more complex cases, reach out to Microsoft’s official support channels for expert assistance. Following these steps can help you overcome common issues with Office 2021.